Kazano Side Effects

Only on the market since January 2013, Kazano contains a combination of alogliptin and metformin and is used for the treatment of type 2 diabetes. The drug works by decreasing the amount of glucose produced by the liver. Despite only being on the market for a short time, several Kazano side effects have been reported. Side effects may be mild or severe; temporary or permanent. Kazano side effects include:

Side Effects of Kazano

Lactic Acidosis

Kazano is a combination of two medications, alogliptin, and metformin. Lactic acidosis, a build-up of an acid in the blood is a rare but life-threatening condition caused by medication metformin. Lactic acidosis is more likely to occur in diabetic people who have the previous history of liver and kidney problems; gets dehydrated ( loose large amount of fluid); congestive heart failure; surgery; heart attack; severe infection, stroke, and X-ray or scanning procedures that use injectable contrast dye.

People who drink a lot of alcohol (very often or short-term “binge” drinking) may also have a higher chance of getting lactic acidosis. Sign and symptoms associated with lactic acidosis include unusual stomach pain; feel cold, especially in your arms and legs; unexplained stomach or intestinal problems with nausea and vomiting, or diarrhea; unusual sleepiness or sleep longer than usual; trouble breathing; unusual (not normal) muscle pain; and feel very weak or tired. Consult your healthcare provider if you experience any of the above symptoms.

Pancreatic Cancer

People with type 2 diabetes using Kazano medication are at higher risk of having pancreatic cancer. The sign and symptoms of pancreatic cancer include dark urine; clay-colored stools; fatigue, weakness, jaundice; loss of appetite, weight loss; nausea, vomiting; pain or discomfort in the upper part of the belly or abdomen, back pain; blood clots; diarrhea and indigestion. It is advisable to seek medical attention in case of severity.

Thyroid Cancer

In addition to increasing the risk of pancreatic cancer, Kazano may also have the potential to cause thyroid cancer. Clinical trials have reported that the drug has a direct effect on the immune system. Signs and symptoms of this life-threatening side effect include lumps/nodules in the neck; hoarseness/changes to the voice; swallowing or breathing problems; pain in the throat/neck; swollen lymph nodes in the neck; cough not caused by other conditions; enlarged thyroid gland. Consult your health care provider in case of an emergency.

Allergic Reactions

Allergic reactions are very common side effects associated with Kazano medication. In the initial phase of treatment, people have a mild rash. Some people may experience severe skin allergic reactions which are accompanied by itching or swelling on the face, tongue or throat; fever, difficulty in swallowing or breathing; and hives. Some people may also experience painful skin rash on the face and upper part of the body. These painful rashes are usually of a reddish color and may cause flaking or peeling of the skin. The symptoms can be reversed by the discontinuation of Kazano medication. Call your health care provider immediately in case of severe allergic reactions.

Liver Problems

Kazano medication may also cause severe problems for your liver. The sign and symptoms of the liver problems include pain or swelling in the stomach; unusual and unexplained fatigue, dark colored urine and loss of appetite. Patients may also suffer from jaundice, a disease characterized by yellowing of the skin and whites of the eyes. Consult your doctor if your skin has turned yellow or any of the above symptoms persists.


Hypoglycemia, low blood sugar is another severe Kazano side effect. The mediation itself does not cause side effects. However, hypoglycemia occurs when Kazano is taken in combination with another anti-diabetic medication such as sulfonylurea or insulin. Talk to your healthcare provider about all your diabetic medication before taking Oseni.

Signs and symptoms of low blood sugar include shakiness or jittery feeling; change in mood, such as irritability; sudden sweating, fast heartbeat, hunger, blurred vision, dizziness and tingling in hands and feet. Patients having hypoglycemia should carry sugar/glucose tablets to increase the level of blood sugar in the body.

In case you don’t have a tablet and you are experiencing any of the above symptoms then you can immediately take sugar candy, honey, or non-diet soda. Hypoglycemia mainly occurs due to the consumption of fewer calories, or unusually heavy exercise or consumption of alcohol. Eat your food regularly. Consult your doctor in case of severe symptoms.

Common Side Effects

The most common Kazano side effects include cold-like symptoms that are accompanied by runny or stuffy nose and sore throat; and back pain. People may also experience mild symptoms like diarrhea, increased blood pressure, headache and urinary tract infection. It is advisable not to ignore these side effects and seek medical attention immediately. If left untreated, Kazano’s side effects may prove fatal.


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